Understanding the pharmacokinetics (PK) and pharmacodynamics (PD) of your test compounds (e.g. small or large molecules, antibodies and even nucleic acids) is essential at all stages of the drug discovery and development process.
The main objective of preclinical PK/PD studies is to determine the levels of the test article and corresponding biomarkers in both circulation and target organs in living organisms, in order to understand the correlation between them. This information is vital to support dosing regimens, toxicology studies and formulation development. We have expertise with different models in rodents:
- Syngeneic tumor models
- Xenograft in immunocompromised animals
- Inflammatory bowel disease model
- Pancreatitis model
- Kidney injury models
- Toxicology
- Pharmacokinetics
- Others
"Our preclinical pharmacology experts will provide complete support for your study, from formulation to preclinical models, with fast turnaround times."
